Pope Francis has come to the chief shrine to Cuba's patron saint for the final Mass of his visit to the island nation before heading to the United States.
President Raul Castro received the pontiff at the basilica of the Virgin of Charity in the town of Cobre.
Pope Francis is calling on Cubans to rediscover their Catholic heritage and live a "revolution of tenderness," highly evocative words in a country whose 1959 socialist revolution installed an officially atheist government that was long hostile to religion.
The pope says: "Our revolution comes about through tenderness, through the joy which always becomes closeness and compassion, and leads us to get involved in, and to serve, the life of others."
Pope Francis has concluded his Mass at the Sanctuary of the Virgin of Charity of Cobre outside the eastern city of Santiago.
The pope asked the Virgin to give Cubans "what they most desire and most need."
Two children gave him a copy of a century-old letter from islanders to Pope Benedict XV asking him to declare the Virgin the patroness of Cuba.
He now travels to the Cathedral of Santiago to bless families.
Twitter has rolled out special emojis for users tweeting about Pope Francis' visit to the United States.
Tweets with the hashtag "PopeInUS" render an icon of a smiling, white-capped pontiff in front of a U.S. flag.
There are also emojis for #PopeInDC - the U.S. Capitol; #PopeInNYC - the Statue of Liberty; and #PopeInPhilly - the Liberty Bell.
Francis wraps up a four-day Cuba trip today and flies north to the United States.
In his final formal event in Cuba, the pope has called on Cubans to strengthen the bonds of family, which he calls "true spaces of freedom."
He says the breakup of families fragments societies or makes them uniform. He says that in both cases, "people turn into isolated individuals, easy to manipulate and to rule."
After the remarks at the Cathedral of Santiago, he's heading to catch a flight to Washington to begin the U.S. leg of his trip.
Pope Francis has departed Cuba for a roughly three-hour flight to Washington after calling on islanders to live a "revolution of tenderness."
His words capped a four-day trip marked by warm interactions with Cuba's leaders and subtle critiques of the system they run.
At Sunday Mass in Havana, Francis urged Cubans to serve one another rather than an ideology. He encouraged them to refrain from "looking to one side or the other to see what our neighbor is doing or not doing." Those remarks resonated in a nation where the government controls most aspects of life.
He held what appeared to be friendly meetings with Fidel and Raul Castro, the former and current presidents of Cuba. Raul Castro has accelerated a warming with the church that began under his brother, and has spoken admiringly of Francis and his critiques of global capitalism.
The pope also spoke in the foothills of the Sierra Maestra mountains where Fidel Castro commanded a guerrilla army that swept to power in 1959.
Francis said Tuesday: "Generation after generation, day after day, we are asked to renew our faith. We are asked to live the revolution of tenderness as Mary, our Mother of Charity, did."
The visit by Pope Francis to the U.S. will mark his second meeting with President Barack Obama.
They first met in March 2014 at the Vatican.
Afterward, the Vatican and the White House offered differing accounts of what the leaders discussed during their nearly hour-long meeting.
Obama stressed their common ground on fighting inequality and poverty while Vatican officials emphasized the importance to the Roman Catholic Church of what they called "rights to religious freedom, life and conscientious objection."
That point referred to a major disagreement over mandatory contraceptive coverage under Obama's health care law.
For the first time in his presidency, Barack Obama is greeting a visiting dignitary at the point of touchdown - Andrews Air Force Base.
The president and first lady Michelle Obama decided to be at the foot of the airplane stairs at Andrews to welcome Francis when he arrives in the U.S. for the first time, in late afternoon.
Presidents usually have important visitors come to them, at the White House. But for the pope's predecessor, Benedict XVI, President George W. Bush and Laura Bush travelled to the air force base in Maryland to greet him.
Francis comes to the White House on Wednesday morning. Some 15,000 people have been invited to the arrival ceremony on the South Lawn.
Welcome to our live coverage of Pope Francis' first-ever visit to the United States. Follow along for continuing coverage of the pope's events in Washington D.C., New York and Philadelphia starting today and going through Sunday.
The pope left Cuba earlier today and is expected to land at Joint Base Andrews just outside of Washington in a little over an hour from now. Check out photos from his four day in Cuba...
Did you know the pope is on Twitter? He sent this out after taking off from Santiago earlier today.
And yes, it does appear the pope just made a giant loop over North Carolina.
Pope Francis will be greeted when he lands by President Obama and first lady Michelle Obama. Check out image of past presidential papal visits...
Here are some of the people who will greeting Pope Francis when his plane arrives:
President Barack Obama
First Lady Michelle Obama
Mrs. Marian Robinson
Vice President Joe Biden
Dr. Jill Biden
Maisie Biden (Granddaughter of the Vice President)
Finnegan Biden (Granddaughter of the Vice President)
Peter Selfridge, Chief of Protocol of the United States
Ambassador Kenneth Hackett
Cheers from the crowd at Joint Base Andrews as Pope Francis' plane touches down on U.S. soil.
It's raining just a little as the pope prepares to walk off the plane.
Seems like Fiat is pretty happy with the pope's vehicle choice...
Pope Francis' schedule for Wednesday:
9:15 a.m.: Pope Francis meets with President Obama at the White House.
11 a.m.: Papal Parade along the National Mall.
11:30 a.m.: Prayer at Saint Matthew's Cathedral with U.S. bishops.
4:15 p.m.: Canonization Mass at the Basilica of the National Shrine of the Immaculate Conception.
Good morning! Pope Francis is expected to arrive at the White House shortly.